【摘 要】
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Understanding how changes in gene function affect tumorigenesis is crucial for elucidating cancer biology and identifying therapeutic targets.Numb and Numbl
【机 构】
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Dept.ofMolecular,Cellular&DevelopmentalBiologyYaleUniversity219ProspectStreet,KBT616BP.O.Box208103
【出 处】
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第四届吴宪吴瑞国际学术研讨会、第九届全国医学生物化学与分子生物学、第六届全国临床应用生物化学与分子生物学联合学术讨论会
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Understanding how changes in gene function affect tumorigenesis is crucial for elucidating cancer biology and identifying therapeutic targets.Numb and Numbl are mammalian homologues of Drosophila numb, a protein that segregates asymmetrically for the two daughter cells to choose different fates after an asymmetric division by inhibiting Notch.Breast cancers with lower Numb levels display poorer prognosis, and Numb loss is believed to play a determinative role in cancer development by simultaneously activating Notch, an oncogene,and degrading p53, a tumor suppressor.
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