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Thyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor,is postnatally expressed in discrete areas of the hypothalamus and closely linked to the neuroendocrine regulations.We previously reported that TTF-1 transcriptionally regulates expression of α-melanocyte-stimulating hormone (α-MSH) and agouti-related peptide (AgRP) in the rat arcuate nucleus and affects feeding behavior via the melanocortinpathway.