【摘 要】
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Background Challenges of virologic failure (VF) after combination antiretroviral therapy (cART) remain substantial in resource limited settings.The objectives of the present study were to evaluate the
【机 构】
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Department of Infectious Diseases, Peking Union Medical College Hospital,Chinese Academy of Medical
【出 处】
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中华医学会第六次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议
论文部分内容阅读
Background Challenges of virologic failure (VF) after combination antiretroviral therapy (cART) remain substantial in resource limited settings.The objectives of the present study were to evaluate the potential utility of therapeutic drug monitoring (TDM) of nevirapine to lower the rates of VF among Chinese HIV-infected patients.Methods Longitudinal data were pooled from a multi-center clinical trial between 2009 and 2010 across mainland China.A total of 525 cART-na? ve patients receiving NVP-containing regimens were enrolled with NNRTI/NRTI sensitivity confirmed at baseline.Plasma concentrations of NVP were measured 0 to 15 hours postdose at week 2, 4, 12, 24, 36, and 48.Abnormally low plasma concentration (ALC) was defined as either of: (1) ＜ 1 μg/mL, or (2) ＜ 3 μg/mL while more than 3 μg/mL different from the highest recorded concentration of the same patient.VF was defined as any of (1) plasma HIV-1 viral load (VL) ＞400 copies/mL after week 24 of cART, or (2) plasma HIV-1 VL ＞ 50 copies/mL after 48 weeks of cART, or (3) constitutive increase of VL after initial suppression.Patients with early identified ALC at Week 4 and 12 received further adherence support.The benefit of adherence support and value of ALC as a prognostic factor before VF were analyzed.
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