JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylati

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：zhghliu

【摘要】

：

Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence.

【作者】

：

Li Zhao Baiqu Huang

【机构】

：

The Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, C

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

JMJD3 senescence-associated heterochromatin foci (SAHF) RB lysine demethylation

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　　Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence.

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JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylati

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