Gut microbiota, as the second genome for humans, must be in harmonious integration with the first genome to sustain a healthy immunity and metabolism for the host.In animal models, it has been shown that high-fat diet can disrupt gut microbiota to increase population levels of opportunistic pathogens and decrease the levels of gut barrier protecting bacteria.Long term dysbiosis would lead to increased antigen load in host blood stream to provoke an unresolved chronic inflammation damaging insulin receptor, vessel walls etc for development of metabolic diseases.