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Objective: To detect hemispheric lateralization with the findings of fTCD in contributing to early diagnosis of VCI.Method: Consecutive cooperative AD (n=32) ,VaD (n=27)and VCIND (n=36) in patients were recruited from 1st Affiliated Hospital of Nanhua University, between October 2011 and October 2013.Patients and care-takers were givendetailed information sheets and signed informed consent before undergoing the consent procedure.All subjects information sheets and consent forms were proved by Medical Ethics Committee of 1st Affiliated Hospital of Nanhua University.Normal controls (NC) were defined as subjects without any subjective cognitive complaints or functional loss who scored ≥23 on the Mini Mental State Examination (MMSE) if they had secondary/tertiary education, or scored ≥21 if they had primary/no education on initial screening and subsequently had no significant cognitive impairments on formal neuropsychological testing.