Acidotoxicity is common among many neurological diseases,such as ischemic stroke.Traditionally,Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered as the leading cause of acid-induced neuronal death.We show here,however,that extracellular protons trigger a novel form of necroptosis in neurons via ASIC1a,independent of its ion-conducting function.