1H-Time-Domain-NMR is a non-destructive bulk method providing detailed information about the different physical environments of hydrogen during chemical reactions.Low financial impact in maintenance and acquisition offers an already broad usage in quality control and research in polymer and food industry.Allowing both quantitative and physical measurements of hydration products, organic additives and water, it is the most promising laboratory scale method for characterizing interactions between organic substances and cement under in-situ conditions otherwise hardly accessible by standard methods commonly known in cement chemistry.In order to demonstrate and evaluate the range of applications for this method a detailed description will be provided for the data acquisition and processing requirements for cementitious systems under in-situ conditions along with hydration studies combined with standard methods highlighting the value of the supplementary insights from in-situ 1H-TD-NMR.The possibility to follow in high detail the interactions and reactions between organic additives and cementitious systems will open new potentials for the development of optimized products and applications.