【摘 要】
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Aim:A meta-analysis was performed to assess the efficacy and safety of tacrolimus monotherapy (TM) in liver transplantation.Study:PubMed/Medline,EMBASE,the Cochrane Library,and Google Scholar were sea
【机 构】
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First affiliated hospital,school of medicine,zhejiang university
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Aim:A meta-analysis was performed to assess the efficacy and safety of tacrolimus monotherapy (TM) in liver transplantation.Study:PubMed/Medline,EMBASE,the Cochrane Library,and Google Scholar were searched to identify randomized controlled trials (RCTs) that assess the efficacy and safety of tacrolimus monotherapy (TM) in liver transplantation.After a methodological quality assessment and data extraction,the pooled estimates of incidence of early mortality,patients and graft survival,incidence of acute rejection and the side-effects such as renal insufficiency,de novo arterial hypertension,de novo diabetes mellitus,Neurotoxicity,CMV infection and hypercholesterolemia post-transplantation,were calculated.We calculated pooled estimates of odds ratios (OR) by fixed-and/or random-effects models.We also assessed heterogeneity among studies and the publication bias.
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