Aims: β-arrestins, including β-arrestin1 and β-arrestin2, are multifunctional adaptor proteins.Recently, some new roles of β-arrestins in regulating intracellular signaling networks have been discovered, which regulate malignant cell functions.Altered expression levels of β-arrestins have been reported in many cancers, but its role in hepatocellular carcinoma (HCC) is not clear.