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The structure of theplasma membrane Ca2+ATPases (PMCA pumps) consists of 10 transmembranedomains, two large cytosolicloops, one of whichcontains the catalytic center, and acytosolicC-terminal regulatoryregion, where a calmodulinbinding domain (CaM-BD) islocated.In nonactivatedconditions (IownMcalcium in the environment), the C-terminal tail of the pumpinteracts with autoinhibitorysitesproximal to the activecenter of the enzyme,maintaingitinhibited.