【摘 要】
：
Chemotherapy is one of the most promising therapeutic strategies in oncology,but the poisonous side effect and lack of targeting selectivity restrict their
【机 构】
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Department of Orthopedics,The Second Hospital of Jilin University,Changchun 130041,China
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Chemotherapy is one of the most promising therapeutic strategies in oncology,but the poisonous side effect and lack of targeting selectivity restrict their in-depth applications [1,2].The sustained drug delivery systems based on polymer-drug conjugates have been used to solve the above problems [3].In this work,the cis-aconitic anhydride (CA) modified doxorubicin (DOX) (i.e.,CAD) was conjugated onto the terminal hydroxyl group of poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PLGA-b-PEG-b-PLGA),yielding CAD-PLGA-b-PEG-bPLGA-CAD prodrug (Scheme 1).The prodrug aqueous solution was liquid at a lower temperature (such as 4 ℃),while transformed into gel at a higher temperature (such as body temperature,37 ℃).
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