【摘 要】
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Controlling the dynamics of DNA translocation is a central issue in the emerging nanopore-based DNA sequencing.In the context of transverse tunneling-current DNA sequencing, we perform atomistic molec
【机 构】
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Department of biotechnology and bioinfomatics, Korea university, Sejong, Korea
【出 处】
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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
Controlling the dynamics of DNA translocation is a central issue in the emerging nanopore-based DNA sequencing.In the context of transverse tunneling-current DNA sequencing, we perform atomistic molecular dynamics (MD) simulations for the singlestranded DNA translocating between the two nanoelectrodes: capped carbon nanotube (capCNT) electrodes and nitrogen-doped capped carbon nanotube (N-capCNT) electrodes.Detailed analysis of the MD simulation results showed that N-capCNT stabilizes the edge-on configuration of nucleobases and slows down the DNA translocation speed by forming hydrogen bond.
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