人胰岛消化分离的实验研究

来源 :2014中国器官移植大会 | 被引量 : 0次 | 上传用户：dingdingdeaiqing85

【摘要】

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【作者】

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张耀辉陈浩傅红兴赵佳聪王雁严盛郑树森

【机构】

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浙江大学医学院附属第一医院卫生部多器官联合移植研究重点实验室温州医学院药学院

【出处】

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2014中国器官移植大会

【发表日期】

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2014年5期

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目的:在1型糖尿病治疗上,尽管目前已经普及了血糖监测和胰岛素的规范化使用,但仍有许多患者无法控制血糖,甚至出现严重的低血糖反应.而胰岛移植通过重建患者血糖生理性调控功能,避免了因胰岛素使用引起的低血糖反应,降低了糖尿病并发症,同时减少了生活中服药及注射胰岛素的麻烦,是一种非常有前景的治愈1型糖尿病的手段.目前认为,人胰腺分离胰岛每例达到约200000IEQs以上即可达到一次临床移植的量.而一般的纯化过程会损失20％至30％的胰岛量,即胰腺消化收集到约290000IEQs以上即可保证纯化及移植的胰岛数量.本实验使用CIT (NIH Clinical Islet Transplantation)方法分离胰岛,详细记录每一个步骤,并探讨影响胰岛分离的因素.

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人胰岛消化分离的实验研究

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