【摘 要】
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Objective: Immune status assessment of DC-CIK treated patient is an important basis for prognosis estimation.A systematic analysis was carried out to disclose the relationships among serological, immu
【机 构】
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Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical Univer
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Objective: Immune status assessment of DC-CIK treated patient is an important basis for prognosis estimation.A systematic analysis was carried out to disclose the relationships among serological, immunological indicators, Quality-of-life score (QoL-score) , and long-term prognosis of patients with malignant neoplasm.Methods: 72 cases of DC-CIK treated patients were randomly enrolled.The composition changes of T lymphocytes cells, regulatory T cells, CIK cells and myeloid-derived suppressor cells (MDSC) cells were detected by flow cytometry, and serum tumor biomarkers of AFP, CEA, CA 19-9, CA 125,CA724 and CA242 were tested by enzyme immunoassay.Prognosis and quality of life assessment were evaluated by EORTC QLQ-C30 designed by European Organization for Research and Treatment of Cancer.
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