Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of

来源 :中国CDC职业卫生与中毒控制所2015学术年会 | 被引量 : 0次 | 上传用户:kxianwen
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  Several studies have suggested that maternal exposure to Polychlorinated dibenzo-p-dioxins (PCDDs),poly-chlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs) may affect foetal growth and infant development.The aim of our study was to determine whether the childbearing-aged residents living near a chemical plant have a greater exposure risk.Concentrations of 17 PCDD/Fs congeners and 12 non-ortho and mono-ortho dioxin-like PCBs were measured using HRGC-HRMS in the blood of 30 non-occupational childbearing-aged women living near a chemical plant (Dagu) that had been producing chlorinated pesticides from 1958 to 2004.The factors that influenced the body burden were investigated based on responses to a questionnaire.Levels of PCDD/Fs + PCBs were in the range of 16.43-155.29 pg WHO 2005-TEQ g-1 lipid.PCDDs and PCDFs contributed 56.72% and 34.44%,respectively,to the total TEQ value.Total WHO-TEQ was approximately tenfold higher in the participants living in the vicinity of the plant (distance: 1.52 ± 0.148 km) than in the groups living farther away (distance: 4.93 ± 1.124 km).A negative correlation between total WHO-TEQ and distance to Dagu was observed by multiple linear regression models.The data provide basic information for monitoring dioxin-like chemicals in the district and for the future study of the relationship between POPs and pregnancy outcomes.
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