【摘 要】
：
The preparation of biodegradable and thermoresponsive enzyme-polymer bioconjugates with controllable enzymatic activity via reversible addition-fragmentation ch
【机 构】
：
CollegeofChemicalScienceandEngineering;LaboratoryofFiberMaterialsandModernTextile,theGrowingBaseforS
【出 处】
：
Taishan Academic Forum on Graphene Nanomaterials and Biomedi
论文部分内容阅读
The preparation of biodegradable and thermoresponsive enzyme-polymer bioconjugates with controllable enzymatic activity via reversible addition-fragmentation chain transfer (RAFT) polymerization and amidation conjugation reaction is presented.A new 2-mercaptothiazoline ester functionalized RAFT agent with intra-disulfide linkage was synthesized and used as chain transfer agent (CTA) to generate a biocompatible homopolymer,poly(ethyleneglycol) acrylate (polyPEG-A) and a thermoresponsive copolymer of poly(ethyleneglycol) acrylate with di(ethyleneglycol)ethyl ether acrylate [poly(PEG-A-co-DEG-A)].
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