【摘 要】
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The growth hormone secretagogue receptor (GHSR) is a GPCR whose natural ligand is the 28 amino acid peptide ghrelin.Ghrelin agonism of the GHSR in the CNS leads to growth hormone (GH) secretion and in
【机 构】
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Discovery Chemistry Bristol-Myers Squibb USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
The growth hormone secretagogue receptor (GHSR) is a GPCR whose natural ligand is the 28 amino acid peptide ghrelin.Ghrelin agonism of the GHSR in the CNS leads to growth hormone (GH) secretion and increased IGF-1 production in the liver.Orally active Growth Hormone Secretagogues (GHSs) have a potential application for treating frailty in the elderly,osteoporosis,perisurgical or parenteral nutrition.More recent studies have indicated that GHSs may be beneficial in the treatment of cancer cachexia and HIV wasting syndrome.Additionally,new pre-clinical data have demonstrated the potential utility of GHSs for treating multiple GI hypomotility-related disorders.These discoveries have renewed interest in agonists of the GHS receptor.Although the area of growth hormone secretagogue research has been explored for years,only a few compounds were successfully advanced into clinical evaluation.
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