2. 您的位置
3. 首页
4. 会议论文
5. 19-DIH Inhibits ATP Production of Anaerobic Cancer Cells via HIF-1 Pathway

19-DIH Inhibits ATP Production of Anaerobic Cancer Cells via HIF-1 Pathway

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：hetongzhixia

【摘 要】

：

19-DIH,a novel cardenolide,was isolated from the leaves of Calotropis gigantea.Our group have isolated and identified a series of cardenolides from this medicinal plant,many of which possess potent hy

【作 者】

：

Zhiyuan Zheng Zhongbo Zhou Xiaobo Zhou Guo-Yuan Zhu Zhi-Hong Jiang Li-Ping Bai 

【机 构】

：

State Key Laboratory of Quality Research in Chinese Medicine,Macau Institute for Applied Research in

【出 处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

Cardenolide Calotropis gigantea HIF-1 ATP production 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　19-DIH,a novel cardenolide,was isolated from the leaves of Calotropis gigantea.Our group have isolated and identified a series of cardenolides from this medicinal plant,many of which possess potent hypoxia inducible factor 1(HIF-1)inhibitory activity[1-2].

其他文献

偕-二氟烯烃与未活化羧酸的有机光氧化还原催化脱羧交叉偶联反应

单氟烯烃的结构在有机合成，药理学和材料科学的各个领域都发挥着至关重要的作用。[1]然而，大量的烷基源的氧化还原中性直接的单氟烯基化仍然非常具有挑战性。 在此，已经开发出第一个通过有机光氧化还原催化脱羧对天然丰富的未活化羧酸进行的单氟烯基化研究。

会议

脱羧单氟烯烃偕-二氟烯烃有机光氧化还原催化

Kidney-accumulated Ultra-small Melanin Nanoparticles as multifunctional theranostic nanoplatform for

Oxidative stress imbalance has always been considered as a crucial mechanism going with myriads of clinical diseases.As antioxidant therapy is emerging as an innovative strategy,nanoantioxidants posse

会议

antioxidantendogenousphotoacoustic

DNA Encoding to Probe Chemical Diversity

会议

The Antitumor Mechanism of G-Quadruplex Aptamer Encapsulated by Neutral Cytidinyl Lipid DNCA

Endogenous G-quadruplex(G-4)aptamers can regulate various biological processes,through the direct interaction to target protein,affecting the genetic transcription,replication and translation.

会议

G4 AptamerDNCAAntitumor Mechanism

Cyclometalated Ir(Ⅲ)chaperone complexes of curcumin as light-activated prodrugs for cancer therapy

Curcumin has been widely reported as potential anticancer candidate drugs that can inhibit the clonogenicity of cancer cells and induce anti-proliferative and apoptotic effects on drug-resistant cance

会议

Iridium complexphotoactived chemotherapymitochondria

新型热激活延迟荧光探针分子及其生物时间分辨成像应用

目前，生物荧光成像技术已成为生命科学和医药研究的重要工具。现有荧光成像检测模式是以荧光信号发光强度作为目标浓度分析参考，然而由于生物样本复杂性，强度信号易受生物样本影响而导致荧光信号无法准确预测，定量检测困难。

会议

热激活延迟荧光双光子近红外荧光寿命

The stepwise photodamage of organelles by two-photon luminescent ruthenium(Ⅱ)photosensitizers

Photodynamic therapy(PDT)is a promising medical technique which employs low-toxic photosensitizer(PS)to produce toxic reactive oxygen species to kill cancer cells under irradiation.

会议

fluorescent-probe localizationpolypyridyl complexesphotodynamic therapyliving

双模式共轭聚合物纳米粒子的制备及其在病原菌杀伤方面的应用

近几十年来，由病原菌感染引起的公共卫生与安全问题因其危及生命的后果而受到越来越多的关注[1]。在现有的抗菌策略中，光动力疗法(PDT)作为光诱导治疗手段，以其高效、低毒、无创性和潜在的抗耐药能力，引起了人们极大的研究兴趣。在白光照射下，光敏剂能使氧气敏化产生活性氧以破坏细菌的完整性。

会议

共轭聚合物纳米粒子光热治疗光动力治疗抗菌双模式

Exploring metalloproteomes by metal-dissociation thermal stability profiling

Metal binding proteins(MBPs)are widely distributed in living systems.They play key roles indiverse biological processes,including but not limited to catalysis,stabilization of proteinsstructure,and si

会议

Metal-binding proteinsthermal-stability profilingtandem mass tag chemoproteomi

Molecular Engineering of NIR BODIPY Structure for Organic-Molecule-Based Nanoparticles with Enhanced

Engineering a single organic-molecule-based nanoparticle integrating precise diagnosis and effective therapy is of great significance for cancer treatment and future clinical applications but remains

会议

BODIPY molecular engineeringphotoacoustic imagingphotothermal therapytheragno