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  5. Inference on Subgroups and All-comers Cognizant of Logical Relationships Among Efficacy Parameters

Inference on Subgroups and All-comers Cognizant of Logical Relationships Among Efficacy Parameters

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：miao4701730
【摘 要】
：
In one aspect of personalized medicine development,the patient population is thought of as a mixture of two subgroups that might derive differential efficacy,given treatment versus control.An importan
【作 者】
：
Szu-Yu Tang Yi Liu Jason C.Hsu 
【机 构】
：
Ventana Medical Systems,Inc.,85755,USAS Takeda Ph
【出 处】
：
上海交通大学
【发表日期】
：
2016年4期
【关键词】
：
Biomarkers subgroup identification Partition testing consistency logical relatio 
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　　In one aspect of personalized medicine development,the patient population is thought of as a mixture of two subgroups that might derive differential efficacy,given treatment versus control.An important decision to make is whether to target the entire patient population(so-called all-comers),or just a subgroup of the patients.There are logical relationships among efficacy parameters in the subgroups and all-comers.
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