【摘 要】
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Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of DNA and RNA-containing immune complexes(IC).Genom
【机 构】
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Baylor Institute for Immunology Research,USA
【出 处】
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2016年国际树突状细胞研讨会(The 14th International Symposium on Dendriti
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Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of DNA and RNA-containing immune complexes(IC).Genomic approaches have shown that >95%of children with SLE display unique blood signatures,that include type Ⅰ IFN-plasma cell-and neutrophilrelated transcripts.A connection between these signatures seems to exist,as activation of SLE neutrophils with TLR7-agonistic autoantibodies from patients induces the release of DNA that triggers massive IFN production by plasmacytoid DCs(pDCs).
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