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[目的]观察太原市某医院孕妇尿中1-羟基芘含量与新生儿神经行为评分的关系,探讨孕期多环芳烃(PAHs)暴露与新生儿神经系统发育的关系。[方法]高效液相色谱法(HPLC)测定2009年7月至2010年5月在太原市某医院生产并签署知情同意书的152名孕妇的尿中1-羟基芘含量,应用新生儿20项神经行为检查法(NBNA)测定新生儿神经行为发育情况,对NBNA得分与孕妇尿中1-羟基芘含量及孕妇一般情况进行多元线性回归分析,验证其相关性。[结果]152名新生儿神经行为得分中位数为38分,其中有4名新生儿神经行为能力未达正常标准(≤35分),新生儿神经行为得分与孕妇尿中1-羟基芘含量、流产次数、孕妇和配偶年龄、居室外35m内有车流量大的干道呈负相关,与妊娠胎次和妊娠前有避孕措施呈正相关。[结论]孕期多环芳烃的暴露可能导致新生儿神经行为评分的降低。
[Objective] To observe the relationship between urinary 1-hydroxypyrene concentration and neonatal neurobehavioral score in pregnant women in a hospital of Taiyuan and to explore the relationship between PAHs exposure during pregnancy and the development of newborn’s nervous system. [Method] The urinary 1-hydroxy-pyrene content of 152 pregnant women who produced and signed informed consent in a hospital of Taiyuan from July 2009 to May 2010 was determined by high performance liquid chromatography (HPLC). Twenty newborns Neurobehavioral test (NBNA) was used to measure the neurobehavioral development in neonates. Multivariate linear regression analysis was performed between the NBNA score and urinary 1-hydroxypyrene levels in pregnant women and the general situation of pregnant women, and the correlation was verified. [Results] The median of 152 newborns’ neurobehavioral scores was 38 points, of which 4 had no neurobehavioral performance (≤35 points), the newborn’s neurobehavioral score and urinary 1-hydroxy pyrene content , The number of abortions, the age of pregnant women and spouses, there is a negative correlation between the traffic outside the 35m indoor and the arterial traffic, which is positively correlated with the gestational age and contraceptive measures before pregnancy. [Conclusion] The exposure of PAH during pregnancy may result in the decrease of neurobehavioral score in neonates.