人脐带间充质干细胞移植治疗雌鼠压力性尿失禁的转化研究

来源 :2014中国妇产科学术会议 | 被引量 : 0次 | 上传用户：zhuguangxinli

【摘要】

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【作者】

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罗新姚润斯宋泓蒋学风蓝建发帅翰林王晓玉刘秋英王一飞

【机构】

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暨南大学附属第一医院妇科暨南大学生物医药研发基地

【出处】

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2014中国妇产科学术会议

【发表日期】

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2014年8期

【关键词】

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间充质干细胞压力性尿失禁移植治疗

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目的探讨人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,HUCMSCs)移植治疗雌鼠压力性尿失禁(stress urinary incontinence,SUI)的可行性和有效性.方法采用气囊压迫分娩大鼠阴道壁模拟产伤并行双侧卵巢切除建立SD大鼠压力性尿失禁模型,建模两月后行转染pEGFP-N1质粒的间充质干细胞(MSCs)尿道周围注射,检测尿动力学指标后获取泌尿生殖道组织,观察尿道及周围组织和膀胱的形态学变化;荧光显微镜观察实验组标本荧光细胞的分布.

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人脐带间充质干细胞移植治疗雌鼠压力性尿失禁的转化研究

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