PPARα:湿热型糖尿病的潜在治疗靶标

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户:pan07631014
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  临床调查发现湿热型糖尿病在糖尿病中医临床四种分型中发病率最高。湿热型糖尿病主要由高糖高脂饮食诱发,多伴随胰岛素抵抗;且湿热证糖尿病越严重,其胰岛素抵抗越严重。基于中医方证对应,病症结合的临床实践发现张仲景的经典名方葛根芩连汤(葛根,黄连,黄芩,炙甘草四味中药组成)治疗早期糖尿病疗效确切。如何科学解读葛根芩连汤治疗湿热糖尿病作用机制对中医药转化医学很有必要。我们采用均匀设计不同配比葛根芩连汤干预高脂饮食诱发的糖尿病SD大鼠模型,结果显示多个葛根芩连汤干预组产生显著降糖降脂效果,其中重用葛根的配比14组优于阳性药二甲双胍的降糖效果。
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