【摘 要】
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Small interfering RNA(siRNA)is of considerable current interest in biology and medicine because it can elicit potent,target-specific knockdown of any mRNA,c
【机 构】
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Department of Bioengineering,University of Washington,Seattle,WA,98195
【出 处】
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The 6th International Conference on Nanoscience and Technolo
论文部分内容阅读
Small interfering RNA(siRNA)is of considerable current interest in biology and medicine because it can elicit potent,target-specific knockdown of any mRNA,creating a useful and proven genetic surrogate tool.However,as with other antisense approaches,applying siRNA technology can prove challenging.Problems include enhancing siRNA stability,minimizing off-target effects,identifying sensitive sites in the target RNAs,and particularly ensuring efficient delivery.
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