【摘 要】
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Cancer is the leading cause of death in human, while more than 90% of cancer patients die from cancer metastasis.Currently there is no effective treatment for cancer metastasis, this is mainly due to
【机 构】
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Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, P
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Cancer is the leading cause of death in human, while more than 90% of cancer patients die from cancer metastasis.Currently there is no effective treatment for cancer metastasis, this is mainly due to our lack of understanding of pathogenesis, and especially the molecular mechanism of metastasis.To identify the critical genes that play causal roles in cancer metastasis, we applied a piggyBac transposon based genome-wide mutagenesis platform, generated several genome-wide mutagenesis libraries in four tumor cell lines, established in vitro and in vivo organ specific metastasis screening strategies, and identified more than 20 genes whose mutations are involved in tumor metastasis.
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