Content: The small regulatory RNA (sRNA) Pxr prevents the initiation of fruiting body development by the bacterium Myxococcus xanthus under nutrient abundance.Normally starvation triggered the rapid removal of Pxr inhibitor and prompt cells to proceed into the developmental pathway.On the contrary, the OC (GV32) is unable to relay the early starvation signal, hence the Pxr-mediated developmental blockage is constitutively active.