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Pain is a multi-dimentional experience consisting of sensory-discriminative,affective-motivational,and cognitive-evaluative dimentions.In the present presentation,we report how persistent inflammatory pain on one hindpaw can cause plastic changes in network synaptic responses in the dentate gyrus (DG) obtained by multi-electrode array (Med64 system,Alpha-Med Sciences Co.,Ltd.) recordings on acute hippocampal slices of rats receiving subcutaneous injection of bee venom which mimics honeybee sting on mammals.In na(i)ve or saline-control rats,electrical test stimulation (40-200 μA) at molecular layer of the DG where the perforant path fibers terminate could evoke widespread network synaptic responses shown as field excitatory postsynaptic potentials (fEPSPs).The evoked network fEPSPs were mostly confined to the region of DG spatially with either positive-or negative-going fast PS wave followed by a small and slow opposite-going wave.The network responses were intensity-dependent and could be eliminated by perfusion with TTX,high magnesiumlow calcium and CNQX,respectively,but not AP5,suggesting involvement of both pre-synaptic transmitter release and postsynaptic activation of glutamate non-NMDA receptors in production of network fEPSPs.