【摘 要】
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目的 Patients with asthma have a higher incidence of obstructive sleep apnoea (OSA).However, the association between OSA and severe asthma exacerbations remains unclear.In this study, we aimed to invest
【机 构】
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Renmin Hospital of Wuhan University
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
论文部分内容阅读
目的 Patients with asthma have a higher incidence of obstructive sleep apnoea (OSA).However, the association between OSA and severe asthma exacerbations remains unclear.In this study, we aimed to investigate the prevalence of OSA in a cross-sectional study of asthma patients and to prospectively examine the significance of the effect of OSA on severe asthma exacerbations.方法 One hundred and forty-six patients with asthma and 157 matched control individuals were enrolled in this study.The patients with asthma were prospectively studied for 1 year, and exacerbation episodes were identified based on the patients medical histories.The lung function, and percentages of eosinophils in induced sputum were determined, and the frequencies of severe asthma exacerbations during the previous year were evaluated in the group of patients with asthma.结果 The rates of OSA were 19.2％ (28/146) among the patients with asthma and 9.6％ (15/157) among the control individuals (p=0.016).The frequency of severe asthma exacerbations was significantly higher among the asthma patients with OSA compared with those who did not have OSA (p＜0.001).The apnoea-hypopnoea index (AHI) correlated significantly with the number of severe asthma exacerbations (r=0.507, 95％ confidence interval [CI] 0.357 to 0.637, p＜0.001).Logistic regression analysis determined that the AHI was significantly associated with the occurrence of severe asthma exacerbations (odds ratio 1.322, 95％ CI 1.148 to 1.523, p＜0.001).结论 The patients with asthma had a high prevalence of OSA, and OSA was an important factor that was associated with severe asthma exacerbations.
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