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BACKGROUND: Photodynamic inactivation (PI) has been used to deactivate the virus in blood for many years.M007, the derivant of Methylene Blue, is a new photosensitizer possesses high toxicity towards virus and tumor cells.We have confirmed that M007-PCT was a powerful approach for killing tumor cells in-vitro in an early experiment.Our initial hypothesis was that M007-mediated photodynamic inactivation could be used to inactive tumor cells in RBCs reclaimed in cancer surgery.But the toxic effect caused by M007-mediated photochemical treatment (M007-PCT) has not been studied.Methods: The light source used was a Red emitting LED board transmitting red light at 630 nm<λ<660 nm.