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With database survey,we found that there are 227 counterintuitive like-charge guanidinium pairings(Gdm+-Arg pairings)between ligands and receptors in the Protein Data Bank,implying the potential guanidinium-arginine binding between guanidine-containing drugs and their target proteins.We then searched DrugBank database and found that there are 145 guanidine-containing molecules,showing the prevalence of guanidinium groups in drugs.