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We have engineered a DNA vaccine that expresses extracelluar region of murine VEGFR-2 (FLK265-2 493) and 3 copies of C3d (C3d3),a component of complement as a molecular adjuvant,designed to increase antitumor immunity.VEGFR-2 has a more restricted expression on endothelial cells and is upregulated once these cells proliferate during angiogenesis in the tumor vasculature.