Circulating tumor cells as a biomarker to assist low-dose CT for early stage non-small cell lung can

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  Objective Purpose: An analysis of circulating tumor cells was combined with low-dose CT to screen and diagnose early stage lung cancer patients Methods Experimental Design: A total of 2508 subjects with pulmonary nodules identified by low-dose CT were enrolled from a group of 39627 volunteers.After follow-up,24 patients with early stage NSCLC and 54 participates with no pulmonary nodules were included in this study.Cell Collector,an in vivo CTC isolation system,was used to analyze the CTCs.DNA was extracted from both tumor tissues and CTCs and submitted to gene mutation analysis and next-generation sequencing.
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