AIM To observe the antihypertensive effect of linarin combined with luteolin on SHR.METHODS ① The singledose test: The spontaneously hypertensive rats (SHRs) were given linarin combined with luteolin by intragastric administration(ig) for once and blood pressure of 1,2, 4, 6 and 9 h were measured by CODA multi-channel non-invasive pressure measuring system to determine the best-effective-time.② The continuous-dose test: The SHRs were given linarin combined with luteolin by garage 30 d and measuring blood pressure on the 0, 1, 3, 8, 12, 19 and 30 d at the best-effective-time.After the last treatment, blood samples were collected to detect the levels of Ang Ⅱ, ALD, ET, PGI2, TXB2, NO and PRA.③ The hemorheology test: The SHRs were given linatin combined with luteolin for 60 d.On the 60th day, blood samples were drawn from orbit to detect hemorheology indexes.RESULTS linarin combined with luteolin could decrease SBP which might be maintained more than 6 h in single-dose.Antihypertensive effect also could be lasted for 30 d in the continuous-dose.Compared with the model control group , the levels of Ang Ⅱ, PRA, ALD, ET in plasma decreased, and the level of NO in serum increased.Additionally, it improved the hemorheology indexes.CONCLUSION Linarin combined with luteolin could decrease the blood pressure of SHR and improve the hemorheology.Its mechanism was potentially connected with restraining the RAAS, rising the serum NO content and reducing the plasma ET content.