【摘 要】
：
目的 研究白芷总香豆素(Cou)对川芎嗪(TMP)在大鼠体内的药代动力学与药效作用影响及相关机制.方法 采用大鼠多次给药法研究TMP单用，及合用Cou后的凝血时间变化：从动物整体、器官(在体肠灌流法)、及分子水平(肝微粒体)三个不同层面研究Cou/异欧前胡素对TMP大鼠体内过程的影响、TMP跨膜吸收机制及Cou/欧前胡素/异欧前胡素对TMP代谢产物生成影响.结果 Cou能显著延长TMP在大鼠体内抗
【机 构】
：
天津中医药大学中药学院,天津 300193 天津中医药大学中药学院,天津 300193;天津市现代
【出 处】
：
第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议
论文部分内容阅读
目的 研究白芷总香豆素(Cou)对川芎嗪(TMP)在大鼠体内的药代动力学与药效作用影响及相关机制.方法 采用大鼠多次给药法研究TMP单用，及合用Cou后的凝血时间变化：从动物整体、器官(在体肠灌流法)、及分子水平(肝微粒体)三个不同层面研究Cou/异欧前胡素对TMP大鼠体内过程的影响、TMP跨膜吸收机制及Cou/欧前胡素/异欧前胡素对TMP代谢产物生成影响.结果 Cou能显著延长TMP在大鼠体内抗凝血时间(P＜0.05)，且Cou组凝血时间与对照组相比无统计学差异(P＞0.05)； Cou与异欧前胡素均能显著增加TMP单次给药后在大鼠体内的暴露水平，延长滞留时间(P＜0.05)：TMP为被动吸收药物；Cou/欧前胡素/异欧前胡素呈浓度依赖性抑制TMP代谢产物川芎醇的生成.结论 Cou能通过抑制TMP在大鼠体内的代谢而增加其体内暴露水平，继而影响其药效作用.
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