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Objective: Nifedipine is a calcium channel blocker that is widely used in the treatment of cardiovascular disease.It is a substrate of cytochrome P450 3A isoenzymes (CYP3As) and transporter P-glycoprotein (P-gp, ABCB 1).However, significant individual variances in the disposition of nifedipine have been reported, and genetic factors are considered to have important roles.