干扰肿瘤代谢途径的天然抗癌产物Bouchardatine的机制研究

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：angelfang555

【摘要】

：

由于肿瘤具有不同于正常细胞的代谢特征,因此针对肿瘤代谢的关键蛋白进行定向的小分子干预,能在不影响正常细胞的情况下产生抗癌效果[1],是一种新的药物治疗策略。我们新近发现芸香科植物Rutaecae(Bouchardatia neurococca)中提取的天然降脂分子Bouchardatine(Bou)[2-3]可通过激活HCT116 细胞系中的SIRT1-PGC-1α-UCP2 通路,上调解偶联蛋白

【作者】

：

许耀豪宋芹芹李婵胡宇涛宋兵兵叶冀明饶勇黄志纾

【机构】

：

药物化学研究所,中山大学药学院,广州,510002

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

Bouchardatine 肿瘤代谢 UCP2 PGC-1α SIRT1

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干扰肿瘤代谢途径的天然抗癌产物Bouchardatine的机制研究

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