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Background To evaluate the effect of a new regimen of high bolus tirofiban administration on the myocardial perfusion.Methods From October 2009 to October 2010, a total of 195 consecutive patients with STEMI eligible for primary PCI were randomly assigned to either study group (n=99) or control group (n=96).All patients were pretreated with intravenous tirofiban in the emergency room immediately after diagnosis was confirmed.Patients in the study group received additional bolus tirofiban injection immediately after first restoration of antegrade flow, while patients in the control group received intracoronary administration of 0.9% sodium chloride of the same volume as study group in the same way.Angiographic characteristics between the two groups were compared.