三维斑点追踪技术评价MYBPC3基因突变所致肥厚型心肌病患者左心室收缩功能

来源 :中华医学会第十五次全国超声医学学术会议 | 被引量 : 0次 | 上传用户：tianwang782

【摘要】

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【作者】

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左蕾

【机构】

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第四军医大学西京医院 710032

【出处】

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中华医学会第十五次全国超声医学学术会议

【发表日期】

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2015年11期

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目的:研究三维斑点追踪技术(3D-STI)评价MYBPC3基因突变所致家族性肥厚型心肌病(FHCM)患者左室的早期收缩功能及其与心肌厚度的关系.方法:对一个HCM家系进行研究,利用靶向外显子捕获测序的方法对上述HCM家系的先证者的96个与遗传性心肌病相关的基因进行了全部外显子的扩增和高通量测序,进一步通过sanger测序法在其他9位家系成员以及300个健康志愿者中进行验证.常规超声检测左室壁厚度、左房容积、左室舒张及收缩末径、左室射血分数(LVEF)等.三维应变应用Philips iE33超声诊断仪获得和分析二维图像,利用X5-1矩阵探头获取左室三维全容积动态图像,运用TomTec脱机软件对左室局部及整体纵向应变、圆周应变、径向应变、总体应变等三维参数进行分析.

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三维斑点追踪技术评价MYBPC3基因突变所致肥厚型心肌病患者左心室收缩功能

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