论文部分内容阅读
一个极早型阿尔茨海默病家系的遗传分析与病理学研究
【机 构】
:
贵阳医学院人体解剖学教研室 贵阳 550004
【出 处】
:
中国解剖学会2011年年会
【发表日期】
:
2011年1期
其他文献
Glutamate stimulation induces a two-phase cofilin rod formation mediated by both NMDA and non-NMDA r
Objective Cofilin is the major actin-depolymerizing factor in the CNS for regulation of actin dynamics.Neurodegenerative stimuli can induce the formation of cofilin rod, a pathological structure compo
Malignant glioma is the most common and fatal tumor in central nervous system, with the poor prognosis even with the advanced treatments.Seeking new prognostic factors and molecular targets may contri
目的 采用十四种近交系小鼠,观察并比较其在三叉神经痛模型前后对疼痛刺激敏感性的变化。方法 采用眶下神经切断手术制备三叉神经痛模型,记录手术前和手术后第14天小鼠耳廓、后爪和尾对机械痛、热痛刺激的反应。机械痛和热痛分别以von Frey毛和激光热刺激诱发。动物的行为学反应按反应强度进行量化。设假手术对照组,仅暴露同侧眶下神经但不切断。结果 (1)生理状况下,对von Frey毛机械刺激,雄性和雌性M
背景 肌细胞增强因子2D (myocyte enhancer factor-2D,MEF2D)属于转录调节因子MADS-box家族,最初被认为是肌细胞特异性DNA结合蛋白,其蛋白多结合在许多肌特异性基因的调控区域控制转录过程,发挥控制肌细胞分化过程中的基因转录功能。最近的研究表明,MEF2D还参与了多种细胞的信号传导过程,在调节细胞分化、增殖、存活和凋亡等方面发挥着重要的作用。在一些脑退行性疾病细
Objective Cerebral ischemia may contribute to the pathogenesis of Alzheimers disease (AD), however, the neuropathological relationship between these 2 disorders is largely unclear.We investigated axon
Objective Glaucoma, the second leading cause of blindness, is a neurodegenerative disease that is characterized by optic nerve degeneration resulting from apoptotic death of retinal ganglion cells (RG