【摘 要】
：
目的:初步探讨人-β防御素-1,-2,-3mRNA(HBD-1,HBD-2,HBD-3)在女性沙眼衣原体感染宫颈炎中的表达及临床意义.方法:选择沙眼衣原体感染宫颈炎患者32例,给予盐酸米诺环素治疗,一月后20例沙眼衣原体转阴,均纳入病例组,正常对照30例,采用逆转录聚合酶链反应(RT-PCR)技术检测宫颈组织中hBD-1,HBD-2,HBD-3mRNA的表达水平.结果：与正常对照组相比沙眼衣原体感
【机 构】
：
新疆医科大学第一附属医院妇科,新疆乌鲁木齐市830054
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目的:初步探讨人-β防御素-1,-2,-3mRNA(HBD-1,HBD-2,HBD-3)在女性沙眼衣原体感染宫颈炎中的表达及临床意义.
方法:选择沙眼衣原体感染宫颈炎患者32例,给予盐酸米诺环素治疗,一月后20例沙眼衣原体转阴,均纳入病例组,正常对照30例,采用逆转录聚合酶链反应(RT-PCR)技术检测宫颈组织中hBD-1,HBD-2,HBD-3mRNA的表达水平.
结果：与正常对照组相比沙眼衣原体感染组HBD-2,HBD-3的表达水平明显增高( P=0.019,0.000),而HBD-1mRNA表达水平与正常对照组相比,无统计学意义(P＞0.05);感染组治疗前后HBD-2,HBD-3mRNA的表达水平相比,差异有统计学意义(P=0.012,0.009),而HBD-1mRNA治疗前后表达水平相比无统计学意义( P＞0.05).
结论:人-β防御素-2,-3mRNA在炎症发生时表达增强,两者相互促进对女性宫颈感染局部免疫防御发挥了重要作用,为今后感染治疗提供了新思路.
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