Background: Previous studies evaluating the association between the xeroderma pigmentosum group G (XPG) Asp1104His polymorphism and head and neck cancer susceptibility have proven controversial.This meta-analysis of the literature was performed to obtain a more precise estimation of the relationship.Materials and Methods: We systematically searched PubMed, Embase and Web of Science with a time limit of Dec 18,2014.Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association.Results: We performed a meta-analysis of eight published case-control studies, including 3,621 cases and 5,475 controls.Overall, no significant association was found between the XPG Asp1104His polymorphism and head and neck cancer susceptibility under all genetic models.In the subgroup analysis by ethnicity, the XPG Asp1104His polymorphism had statistically significant association with elevated head and neck cancer risk under CC vs GG (OR=1.24, 95% CI=1.00~1.54) and the recessive model (OR=1.22, 95%CI=1.01~1.46) in Asian populations.A similar result was found under CC vs GG (OR =1.22, 95%CI =1.01~1.47) in the population based subgroup by source of control.When performed by tumor site, the XPG Asp1104His polymorphism had statistically significant association with elevated laryngeal cancer under all genetic models (CC vs GG: OR=1.59, 95% CI=1.16~2.19;GC vs GG: OR=1.38, 95%CI=1.10~1.72;dominant model: OR=1.42, 95% CI=1.15~1.74;recessive model: OR=1.36,95% CI=1.02~1.81).Conclusions: This meta-analysis suggested that the XPG Asp1104His polymorphism is a risk factor for head and neck cancer susceptibility, especially for laryngeal cancer and in Asian populations.