How Nanotechnology Can Really Improve the Future of Orthopedic Implants and Scaffolds for Bone Defec

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  Aims.As shown in literature, the future strategies to treat bone defects are based on the synergic combination of different methodologies: use of biomimetic scaffold in order to support bone regeneration, use of mesenchymal stromal cells (MSCs) and growth factors.Successful regeneration necessitates the development of tissue-inducing scaffolds that mimic the hierarchical architecture of native tissue extracellular matrix (ECM).Aim of this paper is to explore how nanotechnology can really improve the future of orthopedic implants and scaffolds for bone defects.Here we are going to show the guidelines recently published for the design and development of nanostructured scaffolds for the bone regeneration, and the morphofunctional changing of MSCs interacting with nanogratings.
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