Introduction: Our animal study in chronic stroke rats showed that intracranial implantation of peripheral blood stem cells (PBSC) mobilized by granulocyte colony stimulating factor (GCSF) improved the
Permanent bilateral occlusion of the common carotid arteries in rats is an established experimental model to investigate chronic cerebral hypoperfusion on cognitive function and neurodegenerative proc
Reactive gliosis commonly occurs in brain injury, which is characterized by cellular hypertrophy and glial cell proliferation.In the central nervous system and cerebral-vessel trauma process, thrombin
The effects of ANEPⅢ, a new recombinant neurotoxic peptide, on behavior and brain neuronal activity in animal studies have previously been described.However, whether ANEPⅢ can directly protect neurons
Antitumor-analgesic peptide is a novel recombinant polypeptide with strong analgesic and antitumor effects.Antitumor-analgesic peptide inhibited the writhing response in a dose-dependent manner in a p
Phencyclidine (PCP), an open channel antagonist of the NMDA subtype of glutamate receptor, induces schizophrenia-like behavior in humans and animals and increases glutamate and dopamine release in the
In addition to its key role in complex motor function, the cerebellum is increasingly recognized to have a role in cognition.Thus, congenital, injury or toxicity-induced cerebellar abnormalities have
Bone marrow-derived mesenchymal stem cells (MSCs) are capable of differentiating into multiple cell types.Cell therapy using MSCs has been applied in treating many disorders such as bone defects, dela