AIM To observe the effects of the main active component combinations of a famous Chinese herbal formula "Shuang Shen Tong Guan Fang" composed of ginseng, salvia mihiorrhiza and rhizoma corydalis on myocardium ischemia, and select the combination with the best therapeutic effect, as well as elucidate its therapeutic mechanism.METHODS Based on the previous pharmacochemical, pharmacokinetical and pharmacodynamical studies, six main active compounds of "Shuang Shen Tong Guan Fang" including ginsenoside Rg1, Rb1, salvianolic acid A, rosmarinic acid, tetrahydropalmatine and dehydrocorydaline were selected.The combinations of them were set with the uniform design of 6 × 16, the experimental data of which were analyzed and the combination with the best therapeutic effect was predicted with the multivariant regression analysis.