Metabolomic Profiling of Mice Serum and brain during Toxoplasmosis Progression Using Liquid Chromato

来源 :中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会 | 被引量 : 0次 | 上传用户:liuln6
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests.The aim of this study was to investigate the dynamic changes in the metabolic profile of mouse serum and brain during Toxoplasma gondii infection.
其他文献
Objective: It is known that Toxoplasma gondii could suppress the infective host cell apoptosis,but the mechanism is not known very clearly.
会议
  Objective: To acquire small molecule inhibitors that could significantly reduce the proliferation of Toxoplasma gondii and have no(or low)toxicity to the hu
会议
  Background: Genetic information for Toxoplasma gondii isolates from pigs in eastern,south,and southwestern regions of China has been reported previously.
  The prevalence of infection with Toxoplasma gondii(T.gondii)in humans has been increasing in China due to the growing number of cats in the country.
会议
  Objectives: Several studies have shown that Toxoplasma gondii has developed means to effectively inhibit the host interferon gamma(IFN-γ)-induced the signa
  Toxoplasma gondii microneme proteins(TgMICs)are secreted by micronemes upon contact with host cells,and involved in many biological processes,such as parasi
会议
  Toxoplasma gondii is a medically and economically important protozoan parasite.However,the molecular mechanisms of its sporulation remain largely unknown.
会议
  Toxoplasma gondii,an important protozoan parasite,infects almost all warm blooded animals and humans.
会议
  Toxoplasma gondii,an obligate intracellular parasite,is able to infect many animal species and humans,and can cause toxoplasmosis of the host.
会议
  目的:从家蝇的基因组数据库中筛选获得2 个类几丁质酶基因(chitinase-likeⅠ、Ⅱ),分别克隆这两个基因,对其进行序列分析,构建原核表达载体,获得重组蛋白,为进一步研究家蝇类几