We have been investigated the effect of low-dose-rate radiation (137Cs, 0.7 mGy/h) on DNA repair and other mechanisms in the process of cancer development in AKR/J mice carrying the mouse leukemia vir
Altered gene expression in vivo after low-dose and low-dose-rate irradiation has been observed in a variety of experimental systems.However, few studies actually investigated the underlying mechanisms
Background: A recent study in mice reported early transcriptional response in brain to low-dose X-rays (0.1Gy) suggesting alterations of molecular networks and pathways associated with cognitive funct
Radiotherapy and chemotherapy have been commonly used for the treatment of cancers,but a variety of side-effects due to the normal tissue damage can be caused.
We can classify the compounds that modulate radiation injuries to three categories with respect to the timing of administration: i.e.the compounds for 1) prophylaxis, 2) mitigation, and 3) treatment o
Objective: Nitroxyl compounds have been reported as potential radioprotection drugs.To develop new radioprotectors, a novel chiral nitroxyl compound R-1 was synthesised.
To clarify the biological effects of space environment, especially space radiations, a proposal of "Rad Gene" was performed as the first life science experiment with two human lymphoblastoid cell line
MicroRNA (miRNA) is small non-coding RNA, which plays a key role in cellular response to environmental stresses by regulating gene expression in post-transcription level.
Space environmental condition composed of micro gravity and space radiation, of which the dose is at least one hundred times more compared with that on the earth.