High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphob

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户:christain008
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LMO2 gene is activated as a result of the chromosomal translocation t(11;14)(p13;q11) o r t(7;11)(q35;p13) and del(11)(p12p13) in T-ALL patients.Here we investigate novel rearr angements involving LMO2 in primary samples from TALL patients using fluorescence in situ hybridization (FISH) with tilepath BAC/fosmid clones,array-CGH,and next-generation sequencing techniques.
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