Histone acetylation plays an important role in the regulation of gene expression.The nature product FK228,isolated from Chromobacterium violaceum,exhibits outstanding anticancer activities against an array of tumor cell lines.In addition,it shows high selectivity toward class Ⅰ HDACs.These excellent properties attracted several research groups attention to complete the total synthesis of largazole.Our group have completed the total synthesis of the FK228 from the commercially available material L(-)-Malic acid.