[Objective] To determine the methylation and the expression status of Wnt antagonist Secreted Frizzled-Related Protein 1 (SFRP1) in colorectal cancer and explore the effect of SFRP1 in eolorectal carcinogenesis.[Methods] Reverse-transcription PCR (RT-PCR) and Real-time PCR were used to determine the SFRP1 expression in coloreetal cancer tissues and its adjacent tissues.Methylation-specific PCR ~ (MSP) was used to detect the methylation of.SFRP1 expression in colorectal cancer cell lines was detected by RT-RCR and Western blot.